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VANCOUVER — The Hamilton Tiger-Cats and BC Lions square off for the second time this season to close out Week 10. Hamilton won the first meeting back in Week 3, but have gone 1-4 since. BC picked up an important victory over the Winnipeg Blue Bombers in Week 9 to improve to 2-5. Here’s three keys to victory for each team ahead of Saturday’s 7:00 p.m. ET kickoff, which can be watched on TSN in Canada, on CBSSN in the U.S., and on CFL+ internationally. RELATED » Depth Charts: HAM | BC » Game Notes: Tiger-Cats at Lions » Tickets: Hamilton at BC » Injury Reports: Stay up to date » Who’s gonna win? Play CFL Pick ‘Em presented by Old Dutch now! » Sign up and watch CFL games on CFL+ in the U.S. and Internationally 1. A FOURTH QUARTERBACK Head coach Scott Milanovich will turn to starting quarterback No. 4 on Saturday night when Harrison Frost makes his first career Canadian Football League start. Frost represents a relative unknown for the Lions defence, as he’s appeared in 20 games over three seasons and completed 17 passes for 260 yards. Nine of those completions and 165 of the yards came in relief last week. 2. DEFENSIVE TAKEOVER Hamilton’s defence has been stellar this season and they will need to be again against a Lions offence getting weapons back into the fold. The secondary has allowed 11 passing touchdowns, the second fewest of any team coming into action this week. Defensive backs Devodric Bynum and Jamal Peters will have to keep another talented pivot at bay in Nathan Rourke. 3. STRONGER AS THE GAME GOES ON The Ticats have struggled at inopportune times this season, having allowed 109 of their 234 points in the fourth quarter. Smart decisions and managing the clock to keep the ball out of the hands of the Lions offence is imperative late in the game.